How High-Fat Diet Makes Multiple Sclerosis Worse – Especially Palm Oil

The top panel shows a view of the inside of a neuron where C16 fatty acid derived from palm oil is being synthesized into ceramide C16 (CerC16), which impairs mitochondrial function and results in more severe disease course. The bottom panel shows the same scenario in a mouse with genetic deletions of the ceramide enzymes CerS5 and CerS6. The neurons in these mice do not synthesize Cer C16 from palm oil, resulting in milder disease course. Read Entire Article
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